Advice on buying a house

Hi,

I was hoping to get some advice for how big of a mortgage we can safely handle. My wife and I currently make $330k combined with an additional ~$50k in annual bonuses. We also have long term incentive bonuses that will begin to pay ~$6-10k next year and greatly increase in the next few years (will be upwards of $50k in 2-3 years). We have $20k emergency fund and $215k for a down payment. Houses around us are about $1.5M. We have no CC debt, a $15k car loan and ~$90k in student loans between the two of us. We do pay ~$1.2k a month for a nanny as well.

Can we comfortably afford this?